ketaminetherapyfordepression.org

Therapy with ketamine guide

Research Resource Hub

Central Repository for Research Papers and Datasets

Authored by Michael Alvear

Scholarly Papers & Associated Datasets

Peer-reviewed research with supporting data collections

Research Paper

Coverage Policies for Ketamine-Based Depression Therapies Among Major U.S. Commercial Insurers: Cross-Sectional Analysis of 18 Insurers Covering 85.9 Million Members (August 2025)

We analyzed written coverage policies for Spravato and off-label ketamine (IV/IM/oral) across 18 major U.S. commercial insurers (61.4% of market; 85,884,059 lives).

DOI: 10.5281/zenodo.17113526 | OSF: 10.17605/OSF.IO/6MWS8

Associated Dataset

A Comprehensive Analysis of Coverage Patterns Among Major U.S. Health Insurers

A detailed analysis of ketamine therapy coverage policies across 18 major U.S. health insurance companies, covering over 85.8 million commercial plan members and documenting coverage patterns for Spravato (esketamine), IV ketamine, intramuscular ketamine, and oral ketamine treatments.

Research Paper

Medicaid Coverage of Esketamine and Ketamine Therapies: Cross-Sectional Policy Analysis Across 51 Jurisdictions and 165 Coverage Entities (August 2025)

We reviewed official Medicaid coverage documents from 165 policy-making entities across 51 U.S. jurisdictions (state agencies, MCOs, and PBM carve-outs) captured in August 2025.

DOI: 10.5281/zenodo.17113412 | OSF: 10.17605/OSF.IO/MSR7A

Associated Datasets

Medicaid Managed Care Enrollment by Plan and State: 2022 vs. Latest Market Share Data

Plan-level Medicaid managed care organization enrollment data comparing 2022 figures to the latest month, showing market shares and enrollment numbers across different states and health plans.

State Medicaid vs MCO Enrollment: 2022 to Latest Ratios

State-level summary statistics comparing total MCO enrollment from 2022 to overall state Medicaid enrollment in the latest month, with calculated ratios.

50-State Medicaid Ketamine Policy: Coverage, Requirements, Exclusions

Comprehensive coverage policy information for ketamine therapy across Medicaid plans in all 50 states, detailing coverage status, requirements, and exclusions for different ketamine formulations (nasal spray, IV, IM, and oral).

Research Paper

Geographic Disparities in Medicare Esketamine (Spravato) Access: A Claims-Based Analysis Documenting a 24-State Treatment Desert (September 2025)

In 2023, Medicare Fee-for-Service (FFS) clinic-billed esketamine (Spravato) appears in only 26 states; 24 states report zero clinic-billed use. Our analysis explains why.

DOI: 10.5281/zenodo.17113500

Associated Datasets

2025 Medicare Advantage Enrollment by Parent Organization

This file reports 2025 Medicare Advantage enrollment by parent organization. Each row lists the parent group, covered lives (MA only), market_share_pct, and cumulative_share_pct in rank order, along with source_url/source_title/source_date and last_verified fields indicating whether figures come from KFF’s July 2025 national update or CMS’s August 2025 Monthly Enrollment by Contract.

Medicare Advantage Market Share Enrollment By Carrier

This dataset shows 2025 Medicare Advantage enrollment by parent organization. Each row lists a carrier, the number of covered lives in its MA products, its share of the national MA market, and the cumulative share when ranked from largest to smallest. Source fields document whether the figure comes from KFF’s July 2025 national enrollment update or from CMS’s August 2025 Monthly Enrollment by Contract file.

Research Paper

Who Can Get Ketamine Therapy Under Medicare? A Route-Specific Analysis of Coverage Across Original Medicare, MACs, and Medicare Advantage (September 2025)

Analysis of written coverage policies for Spravato and off-label ketamine (IV/IM/oral) across 18 major U.S. commercial insurers (61.4% of market; 85,884,059 lives).

DOI: 10.5281/zenodo.17113302 | OSF: 10.17605/OSF.IO/D6VJN

Associated Datasets

2025 Medicare Advantage Enrollment by Parent Organization

This file reports 2025 Medicare Advantage enrollment by parent organization. Each row lists the parent group, covered lives (MA only), market_share_pct, and cumulative_share_pct in rank order, along with source_url/source_title/source_date and last_verified fields indicating whether figures come from KFF’s July 2025 national update or CMS’s August 2025 Monthly Enrollment by Contract.

Medicare Advantage Market Share Enrollment By Carrier

This dataset shows 2025 Medicare Advantage enrollment by parent organization. Each row lists a carrier, the number of covered lives in its MA products, its share of the national MA market, and the cumulative share when ranked from largest to smallest. Source fields document whether the figure comes from KFF’s July 2025 national enrollment update or from CMS’s August 2025 Monthly Enrollment by Contract file.

Research Paper

Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary

Comprehensive analysis of 25+ systematic reviews and meta-analyses reveals substantial differences in ketamine therapy effectiveness.

DOI: 10.5281/zenodo.15196895 | OSF: 10.17605/OSF.IO/4BQDS
*

This paper has no associated datasets

Standalone Research Datasets

Independent data collections for research and analysis

DB

Medicaid NEMT (CSV): 50-State Program Details & Booking Contacts

Complete, documented dataset of Medicaid non-emergency medical transportation programs across all 50 states—with booking contacts, scheduling rules, and reimbursement options.

VA

VA Transportation Directory: Contact Database for All 50 States & Medical Centers

Comprehensive contact database for Veterans Affairs transportation services across all 50 states and 134 VA medical centers, providing essential phone numbers for veterans and caregivers needing transportation assistance.

SHIP

Medicare SHIP Directory: Complete Contact Database for All 50 States & DC

Comprehensive contact database for all State Health Insurance Assistance Programs (SHIP) providing Medicare counseling and support services across every U.S. state and the District of Columbia.

NEMT

US Government NEMT Directory – Medicaid, Medicare & VA Transportation Programs by State

Comprehensive directory of 235 government-funded Non-Emergency Medical Transportation (NEMT) programs across all 50 US states and DC. Includes contact information, eligibility requirements, and program details for Medicaid transportation services, Medicare State Health Insurance Assistance Programs (SHIP), and Veterans Affairs transportation programs.